Article
Polygenic selection underlies evolution of human brain structure and behavioral traits
2017-09-09
Abstract excerpt
Seemingly paradoxical characteristics of psychiatric disorders, including moderate to high prevalence, reduced fecundity, and high heritability have motivated explanations for the persistence of common risk alleles for severe psychiatric phenotypes throughout human evolution. Proposed mechanisms include balancing selection, drift, and weak polygenic adaptation acting either directly, or indirectly through selectio...
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Identifiers and source
- Literature Corpus work
- 670755d4-3647-5946-8db1-b6cf2fe53551
- DOI
- 10.1101/164707