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Article

The function of RAD52 N-terminal domain is essential for viability of BRCA-deficient cells.

Nucleic acids research - 16 Dec 2020

Hanamshet Kritika, Mazin Alexander V

Abstract excerpt

RAD52 is a member of the homologous recombination pathway that is important for survival of BRCA-deficient cells. Inhibition of RAD52 leads to lethality in BRCA-deficient cells. However, the exact mechanism of how RAD52 contributes to viability of BRCA-deficient cells remains unknown. Two major activities of RAD52 were previously identified: DNA or RNA pairing, which includes DNA/RNA annealing and strand...

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Identifiers

PMID: 33275133
DOI: 10.1093/nar/gkaa1145
PMCID: PMC7736796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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