Article
A molecular genetic dissection of the evolutionarily conserved N terminus of yeast Rad52.
Genetics - 1 Jun 2002
Mortensen Uffe H, Erdeniz Naz, Feng Qi, Rothstein Rodney
Abstract excerpt
Rad52 is a DNA-binding protein that stimulates the annealing of complementary single-stranded DNA. Only the N terminus of Rad52 is evolutionarily conserved; it contains the core activity of the protein, including its DNA-binding activity. To identify amino acid residues that are important for Rad52 function(s), we systematically replaced 76 of 165 amino acid residues in the N terminus with alanine. These...
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