Article
Functional analyses of the C-terminal half of the Saccharomyces cerevisiae Rad52 protein.
Nucleic acids research - 1 Jan 2014
Kagawa Wataru, Arai Naoto, Ichikawa Yuichi, Saito Kengo, Sugiyama Shusei, Saotome Mika, Shibata Takehiko, Kurumizaka Hitoshi
Abstract excerpt
The Saccharomyces cerevisiae Rad52 protein is essential for efficient homologous recombination (HR). An important role of Rad52 in HR is the loading of Rad51 onto replication protein A-coated single-stranded DNA (ssDNA), which is referred to as the recombination mediator activity. In vitro, Rad52 displays additional activities, including self-association, DNA binding and ssDNA annealing. Although Rad52 has been a...
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