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Article

Homologous recombination in budding yeast expressing the human RAD52 gene reveals a Rad51-independent mechanism of conservative double-strand break repair.

Nucleic acids research - 28 Feb 2017

Manthey Glenn M, Clear Alissa D, Liddell Lauren C, Negritto Maria C, Bailis Adam M

Abstract excerpt

RAD52 is a homologous recombination (HR) protein that is conserved from bacteriophage to humans. Simultaneously attenuating expression of both the RAD52 gene, and the HR and tumor suppressor gene, BRCA2, in human cells synergistically reduces HR - indicating that RAD52 and BRCA2 control independent mechanisms of HR. We have expressed the human RAD52 gene (HsRAD52) in budding yeast strains lacking the endogenous...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27923995
DOI: 10.1093/nar/gkw1228
PMCID: PMC5389729

Genes

RAD52
BRCA2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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