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Article

Interaction with Rad51 is indispensable for recombination mediator function of Rad52.

The Journal of biological chemistry - 18 Oct 2002

Krejci Lumir, Song Binwei, Bussen Wendy, Rothstein Rodney, Mortensen Uffe H, Sung Patrick

Abstract excerpt

In the yeast Saccharomyces cerevisiae, the RAD52 gene is indispensable for homologous recombination and DNA repair. Rad52 protein binds DNA, anneals complementary ssDNA strands, and self-associates to form multimeric complexes. Moreover, Rad52 physically interacts with the Rad51 recombinase and serves as a mediator in the Rad51-catalyzed DNA strand exchange reaction. Here, we examine the functional significance...

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Share to Chromatography, Gel
Share to DNA, Single-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Radiation

Share to Gamma Rays

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Share to Rad52 DNA Repair and Recombination Protein

Source

Identifiers

PMID: 12171935
DOI: 10.1074/jbc.M206511200

Genes

RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction with Rad51 is indispensable for recombination mediator function of Rad52.PMID 12171935Read ↗

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Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activity.Semantic proximity Read ↗

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Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic AdvancementSemantic proximity Read ↗

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