Article
Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain.
Molecular brain - 23 Nov 2020
Kawamura Atsuki, Abe Yoshifumi, Seki Fumiko, Katayama Yuta, Nishiyama Masaaki, Takata Norio, Tanaka Kenji F, Okano Hideyuki, Nakayama Keiichi I
Abstract excerpt
CHD8 encodes a chromatin-remodeling factor and is one of the most recurrently mutated genes in individuals with autism spectrum disorder (ASD). Although we have recently shown that mice heterozygous for Chd8 mutation manifest myelination defects and ASD-like behaviors, the detailed mechanisms underlying ASD pathogenesis have remained unclear. Here we performed diffusion tensor imaging (DTI) and resting-state...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.