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Article

Transcriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability.

Behavioral and brain functions : BBF - 19 Jun 2024

Dalton George D, Siecinski Stephen K, Nikolova Viktoriya D, Cofer Gary P, Hornburg Kathryn J, Qi Yi, Johnson G Allan, Jiang Yong-Hui, Moy Sheryl S, Gregory Simon G

Abstract excerpt

BACKGROUND: Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males and is characterized by atypical verbal/nonverbal communication, restricted interests that can be accompanied by repetitive behavior, and disturbances in social behavior. This study investigated brain mechanisms that contribute to sociability deficits and sex differences in an ASD animal model....

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Identifiers

PMID: 38898502
DOI: 10.1186/s12993-024-00240-3
PMCID: PMC11188533

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