Article

Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespan

2024-09-08

Abstract excerpt

<h4>SUMMARY</h4> Insulating sheaths of myelin accelerate neuronal signaling in complex networks of the mammalian brain. In the CNS, myelin sheaths are exclusively produced by oligodendrocytes, which continue to be generated throughout life to change patterns of myelination. However, a brain-wide analysis of oligodendrocyte dynamics across the lifespan has not been performed. We developed a rapid, robust cellular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a745b98-005e-59a9-b52c-1543c439a442
DOI: 10.1101/2024.09.06.611254

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespanDOI 10.1101/2024.09.06.611254Read

Automated in vivo tracking of cortical oligodendrocytesSemantic proximity Read

Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal ActivitySemantic proximity Read

Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths that are vulnerable to degeneration with ageSemantic proximity Read

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous systemSemantic proximity Read

BMAL1 loss in oligodendroglial lineage cells dysregulates myelination and sleepSemantic proximity Read

Human Myelin Spheres for <i>In Vitro</i> Oligodendrocyte Maturation, Myelination and Neurological Disease ModelingSemantic proximity Read

Single-cell Transcriptomics Analyses Revealed Specialized Microglial Subsets with Oligodendrocyte-like SignaturesSemantic proximity Read

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelinationSemantic proximity Read

Single-Cell Transcriptomic Insights into Conserved and Divergent Oligodendrocyte Lineage Programs Across SpeciesSemantic proximity Read

Local demyelination rekindles oligodendrocyte precursor dynamics and remyelination in old ageSemantic proximity Read

Deep Learning for High-Throughput Quantification of Oligodendrocyte Ensheathment at Single-Cell ResolutionSemantic proximity Read

White matter integrity requires continuous myelin synthesis at the inner tongueSemantic proximity Read