Article

Defects of myelination are common pathophysiology in syndromic and idiopathic autism spectrum disorder

2017-04-18

Abstract excerpt

Autism Spectrum Disorder (ASD) is genetically heterogeneous in nature with convergent symptomatology, suggesting dysregulation of common molecular pathways. We analyzed transcriptional changes in the brains of five independent mouse models of Pitt-Hopkins Syndrome (PTHS), a syndromic ASD caused by autosomal dominant mutation in TCF4, and identified considerable overlap in differentially expressed genes (DEGs). Ge...

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Literature Corpus work: 886b088c-2f9b-58e4-9b52-bdfec2531f4f
DOI: 10.1101/128124

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