Article
Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice.
Human molecular genetics - 28 May 2020
Kawamura Atsuki, Katayama Yuta, Nishiyama Masaaki, Shoji Hirotaka, Tokuoka Kota, Ueta Yoshifumi, Miyata Mariko, Isa Tadashi, Miyakawa Tsuyoshi, Hayashi-Takagi Akiko, Nakayama Keiichi I
Abstract excerpt
Mutations in the gene encoding the chromatin remodeler CHD8 are strongly associated with autism spectrum disorder (ASD). CHD8 haploinsufficiency also results in autistic phenotypes in humans and mice. Although myelination defects have been observed in individuals with ASD, whether oligodendrocyte dysfunction is responsible for autistic phenotypes has remained unknown. Here we show that reduced expression of CHD8...
Topics
- Animals
- Autism Spectrum Disorder
- Chromatin Assembly and Disassembly
- DNA-Binding Proteins
- Disease Models, Animal
- Haploinsufficiency
- Heterozygote
- Humans
- Mice
- Mutation