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Article

Homozygous Loss of Autism-Risk Gene CNTNAP2 Results in Reduced Local and Long-Range Prefrontal Functional Connectivity.

Cerebral cortex (New York, N.Y. : 1991) - 1 Apr 2018

Liska Adam, Bertero Alice, Gomolka Ryszard, Sabbioni Mara, Galbusera Alberto, Barsotti Noemi, Panzeri Stefano, Scattoni Maria Luisa, Pasqualetti Massimo, Gozzi Alessandro

Abstract excerpt

Functional connectivity aberrancies, as measured with resting-state functional magnetic resonance imaging (rsfMRI), have been consistently observed in the brain of autism spectrum disorders (ASD) patients. However, the genetic and neurobiological underpinnings of these findings remain unclear. Homozygous mutations in contactin associated protein-like 2 (CNTNAP2), a neurexin-related cell-adhesion protein, are...

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Identifiers

PMID: 28184409
DOI: 10.1093/cercor/bhx022

Genes

CNTNAP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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