Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus.

doi:10.1186/s13059-020-02184-z

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Article

Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus.

Genome biology - 19 Nov 2020

Raj Prithvi, Song Ran, Zhu Honglin, Riediger Linley, Jun Dong-Jae, Liang Chaoying, Arana Carlos, Zhang Bo, Gao Yajing, Wakeland Benjamin E, Dozmorov Igor, Zhou Jinchun, Kelly Jennifer A, Lauwerys Bernard R, Guthridge Joel M, Olsen Nancy J, Nath Swapan K, Pasare Chandrashekhar, van Oers Nicolai, Gilkeson Gary, Tsao Betty P, Gaffney Patrick M, Gregersen Peter K, James Judith A, Zuo Xiaoxia, Karp David R, Li Quan-Zhen, Wakeland Edward K

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease characterized by the development of anti-nuclear antibodies. Susceptibility to SLE is multifactorial, with a combination of genetic and environmental risk factors contributing to disease development. Like other polygenic diseases, a significant proportion of estimated SLE heritability is not accounted for by common...

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PMID: 33213505
DOI: 10.1186/s13059-020-02184-z
PMCID: PMC7677828

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