Article

eQTL analysis of SLE B cells reveals functional genomic regulatory variation associated with autoimmunity 2253669

2026-07-28

Abstract excerpt

Abstract Introduction Systemic lupus erythematosus (SLE) is a complex and heterogenous autoimmune disease characterized by the expansion of extrafollicular pathogenic B cells derived from newly activated naïve cells. Ultimately the production and deposition of autoantibodies results in damage to multiple organ systems. Therefore, further defining the molecular drivers of extrafollicular B cell differentiation and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fbbfffbc-4973-5edc-bc23-44bf918b294d
DOI: 10.1093/jimmun/vkag141.184

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

eQTL analysis of SLE B cells reveals functional genomic regulatory variation associated with autoimmunity 2253669DOI 10.1093/jimmun/vkag141.184Read

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.Semantic proximity Read

Deciphering cell-specific genetic insights: Unraveling the immunogenetic landscape of systemic lupus erythematosus.Semantic proximity Read

Identification of genetic variants in B cell expressed genes associated with systemic lupus erythematosus in African American females.Semantic proximity Read

A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE)Semantic proximity Read

Genetic advances in systemic lupus erythematosus: an update.Semantic proximity Read

Functional relevance for associations between genetic variants and systemic lupus erythematosus.Semantic proximity Read

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosusSemantic proximity Read

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.Semantic proximity Read

Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and BeyondSemantic proximity Read

Recent advances in understanding the genetic basis of systemic lupus erythematosus.Semantic proximity Read

Genome-Wide Identification of Cell Type-Specific Susceptibility Genes for SLE Through the Analysis of RNA Modification-Associated SNPs.Semantic proximity Read

A review of genetic risk in systemic lupus erythematosus.Semantic proximity Read