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Article

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.

Nature communications - 9 Aug 2024

Wang Qiang, Kim Taehyeung, Martínez-Bonet Marta, Aguiar Vitor R C, Sim Sangwan, Cui Jing, Sparks Jeffrey A, Chen Xiaoting, Todd Marc, Wauford Brian, Marion Miranda C, Langefeld Carl D, Weirauch Matthew T, Gutierrez-Arcelus Maria, Nigrovic Peter A

Abstract excerpt

Genome-wide association studies implicate multiple loci in risk for systemic lupus erythematosus (SLE), but few contain exonic variants, rendering systematic identification of non-coding variants essential to decoding SLE genetics. We utilized SNP-seq and bioinformatic enrichment to interrogate 2180 single-nucleotide polymorphisms (SNPs) from 87 SLE risk loci for potential binding of transcription factors and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39122710
DOI: 10.1038/s41467-024-50710-5
PMCID: PMC11315931

Genes

IKBKE
IKZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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