Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.

doi:10.1038/ng.3434

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Article

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.

Nature genetics - 1 Dec 2015

Bentham James, Morris David L, Graham Deborah S Cunninghame, Pinder Christopher L, Tombleson Philip, Behrens Timothy W, Martín Javier, Fairfax Benjamin P, Knight Julian C, Chen Lingyan, Replogle Joseph, Syvänen Ann-Christine, Rönnblom Lars, Graham Robert R, Wither Joan E, Rioux John D, Alarcón-Riquelme Marta E, Vyse Timothy J

Abstract excerpt

Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous genome-wide association studies (GWAS) had modest sample sizes, reducing their scope and reliability. Our study comprised 7,219 cases and 15,991 controls of European ancestry, constituting a new GWAS, a meta-analysis with a published GWAS and a...

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Identifiers

PMID: 26502338
DOI: 10.1038/ng.3434
PMCID: PMC4668589

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