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Article

Association of blood-based transcriptional risk scores with biomarkers for Alzheimer disease

1 Oct 2020

Abstract excerpt

Objective To determine whether transcriptional risk scores (TRSs), a summation of polarized expression levels of functional genes, reflect the risk of Alzheimer disease (AD). Methods Blood transcriptome data were from Caucasian participants, which included AD, mild cognitive impairment, and cognitively normal controls (CN) in the Alzheimer9s Disease Neuroimaging Initiative (ADNI, n = 661) and AddNeuroMed (n =...

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PMID: 33134515
DOI: 10.1212/nxg.0000000000000517

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