Article
Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1.
G3 (Bethesda, Md.) - 3 Dec 2020
Sanders Elsbeth, Nguyen Phoebe A, Rogers Cody M, Bochman Matthew L
Abstract excerpt
Most eukaryotic genomes encode multiple RecQ family helicases, including five such enzymes in humans. For many years, the yeast Saccharomyces cerevisiae was considered unusual in that it only contained a single RecQ helicase, named Sgs1 However, it has recently been discovered that a second RecQ helicase, called Hrq1, resides in yeast. Both Hrq1 and Sgs1 are involved in genome integrity, functioning in processes...
Topics
- Alleles
- Humans
- Mutation
- RecQ Helicases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins