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Article

Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae.

Genetics - 1 Mar 2000

Mullen J R, Kaliraman V, Brill S J

Abstract excerpt

SGS1 in yeast encodes a DNA helicase with homology to the human BLM and WRN proteins. This group of proteins is characterized by a highly conserved DNA helicase domain homologous to Escherichia coli RecQ and a large N-terminal domain of unknown function. To determine the role of these domains in SGS1 function, we constructed a series of truncation and helicase-defective (-hd) alleles and examined their ability to...

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Identifiers

PMID: 10757756
DOI: 10.1093/genetics/154.3.1101
PMCID: PMC1460973

Genes

BLM
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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