Article
The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.
Molecular and cellular biology - 1 Jan 2012
Groocock Lynda M, Prudden John, Perry J Jefferson P, Boddy Michael N
Abstract excerpt
Of the five human RecQ family helicases, RecQ4, BLM, and WRN suppress distinct genome instability-linked diseases with severe phenotypes, often with indeterminate etiologies. Here, we functionally define Hrq1, a novel orthologue of RecQ4 from fission yeast. Biochemical analysis of Hrq1 reveals a DEAH box- and ATP-dependent 3'-5' helicase activity on various DNA substrates, including bubbles but not blunt...
Topics
- Amino Acid Motifs
- Cisplatin
- Cross-Linking Reagents
- DNA Helicases
- DNA Repair
- DNA, Fungal
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genomic Instability
- Mutation
- RecQ Helicases