Article
A screen for synthetic genetic interactions with the Saccharomyces cerevisiae hrq1ΔN allele.
G3 (Bethesda, Md.) - 10 Dec 2025
Shumaker Kennadi A, Kumcu Michael E, McDevitt Faith E, Rogers Cody M, Bochman Matthew L
Abstract excerpt
The Saccharomyces cerevisiae Hrq1 helicase is a functional homolog of the disease-linked human RECQL4 enzyme and has been used as a model to study RecQ4 helicase subfamily biology. Although the motor cores of Hrq1 and RECQL4 are quite similar, these proteins display distinct N-terminal domains of unknown function. Do these domains facilitate species-specific activities by the two helicases, or do they serve...
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