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Article

Long genes are more frequently affected by somatic mutations and show reduced expression in Alzheimer's disease: Implications for disease etiology.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2021

Soheili-Nezhad Sourena, van der Linden Robert J, Olde Rikkert Marcel, Sprooten Emma, Poelmans Geert

Abstract excerpt

Aging, the greatest risk factor for Alzheimer's disease (AD), may lead to the accumulation of somatic mutations in neurons. We investigated whether somatic mutations, specifically in longer genes, are implicated in AD etiology. First, we modeled the theoretical likelihood of genes being affected by aging-induced somatic mutations, dependent on their length. We then tested this model and found that long genes are...

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Identifiers

PMID: 33075204
DOI: 10.1002/alz.12211
PMCID: PMC8048495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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