Article

Alzheimer's disease: the large gene instability hypothesis

2017-09-15

Abstract excerpt

All drug trials of the Alzheimer's disease (AD) have failed to slow the progression of dementia in phase III studies, and the most effective therapeutic strategy remains controversial due to the poorly understood disease mechanisms. For AD drug design, amyloid beta (Aβ) and its cascade have been the primary focus since decades ago, but mounting evidence indicates that the underpinning molecular pathways of AD are...

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Literature Corpus work: 2da34db3-85ad-5943-b749-3d545ba329bb
DOI: 10.1101/189712

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