Article

An Amyloid Agnostic Reformulation of the Alzheimer’s Disease: The Long Gene Vulnerability Hypothesis

2021-08-23

Abstract excerpt

Alzheimer’s disease (AD) is a genetically complex senile neurodegeneration with unknown etiology. The first gene discovered to be mutated in early-onset AD, the amyloid precursor protein (APP), has been widely assumed as a causal factor in the disease cascade due to its generation of Aβ species. APP has an evolutionarily conserved biological role and activates a signaling program with notable similariti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af7bcf62-70e5-5f4a-bef9-14f7a009d559
DOI: 10.20944/preprints202108.0454.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An Amyloid Agnostic Reformulation of the Alzheimer’s Disease: The Long Gene Vulnerability HypothesisDOI 10.20944/preprints202108.0454.v1Read

Alzheimer's disease: the large gene instability hypothesisSemantic proximity Read

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.Semantic proximity Read

Long genes are more frequently affected by somatic mutations and show reduced expression in Alzheimer's disease: Implications for disease etiology.Semantic proximity Read

The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?Semantic proximity Read

Milestone Review: The History of Molecular Genetics Analysis of Alzheimer's DiseaseSemantic proximity Read

From Common to Rare Variants: The Genetic Component of Alzheimer Disease.Semantic proximity Read

Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the <i> App <sup>NL-G-F</sup> </i> knock-in mouse model of the earliest phase of Alzheimer’s diseaseSemantic proximity Read

Massive changes in gene expression and their cause(s) can be a unifying principle in the pathobiology of Alzheimer's diseaseSemantic proximity Read

Selective neuronal vulnerability in Alzheimer’s disease: a network-based analysisSemantic proximity Read

Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis.Semantic proximity Read

Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences.Semantic proximity Read

De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer diseaseSemantic proximity Read