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Article

Revealing the nervous system requirements of Alzheimer disease risk genes in Drosophila.

American journal of human genetics - 4 Dec 2025

Deger Jennifer M, Hannan Shabab B, Gu Mingxue, Strohlein Colleen E, Goodman Lindsey D, Pasupuleti Sasidhar, Shaik Zahid, Ma Liwen, Li Yarong, Li Jiayang, Stephens Morgan C, Tyrlík Michal, Liu Zhandong, Al-Ramahi Ismael, Botas Juan, Shaw Chad A, Kanca Oguz, Bellen Hugo J, Shulman Joshua M

Abstract excerpt

Most Alzheimer disease (AD) susceptibility genes have poorly understood roles in the central nervous system (CNS). To address this gap, we systematically characterized 100 conserved candidate AD risk genes using a cross-species strategy in the fruit fly, Drosophila melanogaster. Genes were prioritized based primarily on human functional genomic evidence. We generated custom loss-of-function alleles for each of...

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Source

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Identifiers

PMID: 41167194
DOI: 10.1016/j.ajhg.2025.10.003
PMCID: PMC12643326

Genes

ARRB2
BIN1
CD2AP
CLCN1
SNX32
SPI1
STMN4
YOD1

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