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Article

The molecular basis of tight nuclear tethering and inactivation of cGAS.

Nature - 1 Nov 2020

Zhao Baoyu, Xu Pengbiao, Rowlett Chesley M, Jing Tao, Shinde Omkar, Lei Yuanjiu, West A Phillip, Liu Wenshe Ray, Li Pingwei

Abstract excerpt

Nucleic acids derived from pathogens induce potent innate immune responses1-6. Cyclic GMP-AMP synthase (cGAS) is a double-stranded DNA sensor that catalyses the synthesis of the cyclic dinucleotide cyclic GMP-AMP, which mediates the induction of type I interferons through the STING-TBK1-IRF3 signalling axis7-11. cGAS was previously thought to not react with self DNA owing to its cytosolic localization2,12,13;...

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Identifiers

PMID: 32911481
DOI: 10.1038/s41586-020-2749-z
PMCID: PMC7704945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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