Article

Mre11 liberates cGAS from nucleosome sequestration during tumorigenesis

2022-12-10

Abstract excerpt

Oncogene-induced replication stress generates endogenous DNA damage that activates cGAS/STING-mediated innate immune signaling and tumor suppression 1-3 . However, the mechanism for cGAS activation by endogenous DNA damage remains enigmatic, particularly given the constitutive inhibition of cGAS by high-affinity histone acidic patch (AP) binding 4-10 . Here we report an in vivo CRISPR screen that identified the...

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Literature Corpus work: 6d9a07a1-11e5-5f45-90db-7c619d532372
DOI: 10.1101/2022.12.09.519750

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