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Article

Structural mechanism of cytosolic DNA sensing by cGAS.

Nature - 20 Jun 2013

Civril Filiz, Deimling Tobias, de Oliveira Mann Carina C, Ablasser Andrea, Moldt Manuela, Witte Gregor, Hornung Veit, Hopfner Karl-Peter

Abstract excerpt

Cytosolic DNA arising from intracellular bacterial or viral infections is a powerful pathogen-associated molecular pattern (PAMP) that leads to innate immune host defence by the production of type I interferon and inflammatory cytokines. Recognition of cytosolic DNA by the recently discovered cyc...

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Identifiers

PMID: 23722159
DOI: 10.1038/nature12305
PMCID: PMC3768140

Genes

OAS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23722159-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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