Article

The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell death

2018-11-08

Abstract excerpt

<h4>ABSTRACT</h4> Stringent regulation of DNA repair is essential for organismal integrity, but the mechanisms are not fully understood. Cyclic cGMP-AMP synthase (cGAS), the DNA sensor that alerts the innate immune system to the presence of foreign or damaged self-DNA in the cytoplasm is critical for the outcome of infections, inflammatory diseases and cancer. Besides this cytoplasmic function as an innate immune...

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Literature Corpus work: e58e4fb9-bf1d-5a3a-9d3d-733aa5d81a36
DOI: 10.1101/465401

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