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A p97-PML NBs axis is essential for chromatin-bound cGAS untethering and degradation upon senescence-prone DNA damage

2025-10-24

Abstract excerpt

Cyclic GMP-AMP synthase (cGAS), initially identified as a cytosolic sensor for double-stranded DNA, is now widely recognized as a nuclear protein with distinct STING-independent functions. Its presence in the same compartment as genomic DNA highlights the critical need to regulate its nuclear levels to balance the risk of cell-intrinsic immune activation with the recognition of pathogenic DNA. The recent discovery...

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Identifiers and source

Literature Corpus work
cc15b075-9799-57ad-b735-95b2f3e34b39
DOI
10.1101/2025.10.24.684316
Open publication

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A p97-PML NBs axis is essential for chromatin-bound cGAS untethering and degradation upon senescence-prone DNA damageDOI 10.1101/2025.10.24.684316
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