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Article

Structural and functional analyses of DNA-sensing and immune activation by human cGAS.

PloS one - 1 Jan 2013

Kato Kazuki, Ishii Ryohei, Goto Eiji, Ishitani Ryuichiro, Tokunaga Fuminori, Nureki Osamu

Abstract excerpt

The detection of cytosolic DNA, derived from pathogens or host cells, by cytosolic receptors is essential for appropriate host immune responses. Cyclic GMP-AMP synthase (cGAS) is a newly identified cytosolic DNA receptor that produces cyclic GMP-AMP, which activates stimulator of interferon genes (STING), resulting in TBK1-IRF3 pathway activation followed by the production of type I interferons. Here we report...

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Source

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Identifiers

PMID: 24116191
DOI: 10.1371/journal.pone.0076983
PMCID: PMC3792152

Genes

TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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