Article

IPO9 modulates histone-dependent inhibition of cGAS activity

2026-08-25

Abstract excerpt

Cyclic GMP-AMP synthase (cGAS) is a DNA sensor that plays roles in pathogenic infection, cancer, autoimmunity, and genomic instability. Although it was initially described as a cytosolic DNA sensor, cGAS also resides in the nucleus in an inhibited state bound to nucleosome core particles (NCPs). Here, we use integrated phenotypic screening and chemical proteomics to identify a small molecule inhibitor of cGAS acti...

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Literature Corpus work: 3e69548a-472c-5834-a006-d9cb582f9234
DOI: 10.64898/2026.08.24.746556

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