Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

16 Aug 2018

Abstract excerpt

Cyclic GMP-AMP synthase (cGAS) senses double-strand (ds) DNA in the cytosol and then catalyzes synthesis of the second messenger cGAMP, which activates the adaptor MITA/STING to initiate innate antiviral response. How cGAS activity is regulated remains enigmatic. Here, we identify ZCCHC3, a CCHC-type zinc-finger protein, as a positive regulator of cytosolic dsDNA- and DNA virus-triggered signaling. We show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30135424
DOI: 10.1038/s41467-018-05559-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune responsePMID 30135424Read ↗

Innate Immune Response to Cytoplasmic DNA: Mechanisms and DiseasesSemantic proximity Read ↗

Roles of the cGAS-STING Pathway in Cancer Immunosurveillance and ImmunotherapySemantic proximity Read ↗

Structural and functional analyses of DNA-sensing and immune activation by human cGAS.Semantic proximity Read ↗

Regulation of cGAS‐Mediated Immune Responses and ImmunotherapySemantic proximity Read ↗

cGLRs are a diverse family of pattern recognition receptors in animal innate immunitySemantic proximity Read ↗

The triggers of the cGAS-STING pathway and the connection with inflammatory and autoimmune diseasesSemantic proximity Read ↗

Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseasesSemantic proximity Read ↗

Small cytosolic dsDNAs repress cGAS activation and induce autophagySemantic proximity Read ↗

The interactions between cGAS-STING pathway and pathogensSemantic proximity Read ↗

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunitySemantic proximity Read ↗

DNA sensor cGAS-mediated immune recognitionSemantic proximity Read ↗

cGAMP the travelling messengerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.