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Article

Structural mechanism of cGAS inhibition by the nucleosome.

Nature - 1 Nov 2020

Pathare Ganesh R, Decout Alexiane, Glück Selene, Cavadini Simone, Makasheva Kristina, Hovius Ruud, Kempf Georg, Weiss Joscha, Kozicka Zuzanna, Guey Baptiste, Melenec Pauline, Fierz Beat, Thomä Nicolas H, Ablasser Andrea

Abstract excerpt

The DNA sensor cyclic GMP-AMP synthase (cGAS) initiates innate immune responses following microbial infection, cellular stress and cancer1. Upon activation by double-stranded DNA, cytosolic cGAS produces 2'3' cGMP-AMP, which triggers the induction of inflammatory cytokines and type I interferons 2-7. cGAS is also present inside the cell nucleus, which is replete with genomic DNA8, where chromatin has been...

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PMID: 32911482
DOI: 10.1038/s41586-020-2750-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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