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Article

The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling.

Molecular & cellular proteomics : MCP - 1 Jul 2020

Song Bokai, Greco Todd M, Lum Krystal K, Taber Caroline E, Cristea Ileana M

Abstract excerpt

The cyclic GMP-AMP synthase (cGAS) protein is a pattern-recognition receptor of the mammalian innate immune system that is recognized as a main cytosolic sensor of pathogenic or damaged DNA. cGAS DNA binding initiates catalytic production of the second messenger, cyclic GMP-AMP, which activates the STING-TBK1-IRF3 signaling axis to induce cytokine expression. Post-translational modification (PTM) has started to...

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Identifiers

PMID: 32345711
DOI: 10.1074/mcp.RA120.001981
PMCID: PMC7338091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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