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Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases

4 Dec 2019

Abstract excerpt

DNA has been known to be a potent immune stimulus for more than half a century. However, the underlying molecular mechanisms of DNA-triggered immune response have remained elusive until recent years. Cyclic GMP-AMP synthase (cGAS) is a major cytoplasmic DNA sensor in various types of cells that detect either invaded foreign DNA or aberrantly located self-DNA. Upon sensing of DNA, cGAS catalyzes the formation of...

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PMID: 31800327
DOI: 10.1146/annurev-immunol-070119-115052

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