Cytochrome P450 2D6 polymorphism in eastern Indian population.

doi:10.4103/ijp.IJP_530_17

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Article

Cytochrome P450 2D6 polymorphism in eastern Indian population.

Indian journal of pharmacology - 1 Jan 2000

Dhuya Monalisa, Pal Murari Mohan, Hazra Avijit, Chatterjee Suparna, Gogtay Nithya

Abstract excerpt

OBJECTIVES: Cytochrome P450 2D6 (CYP2D6) enzyme metabolizes a quarter of prescription drugs. Polymorphisms of CYP2D6 gene and resultant phenotypic variations in metabolic activity have been described in various populations. We assessed the prevalence of CYP2D6 activity phenotypes, employing dextromethorphan (DXM) as probe drug in subjects with at least two parental generations residing in eastern India. MATERIALS...

Topics

Adult
Cytochrome P-450 CYP2D6
Dextromethorphan
Drug Interactions
Female
Humans
India
Male
Pharmacogenetics
Pharmacogenomic Variants
Phenotype
Polymorphism, Genetic
Young Adult

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Identifiers

PMID: 32874001
DOI: 10.4103/ijp.IJP_530_17
PMCID: PMC7446679

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