Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.

The pharmacogenomics journal - 1 Nov 2016

Dodgen T M, Labuschagne C De J, van Schalkwyk A, Steffens F E, Gaedigk A, Cromarty A D, Alessandrini M, Pepper M S

Abstract excerpt

The relationship between genetic variation in CYP2D6 and variable drug response represents a potentially powerful pharmacogenetic tool. However, little is known regarding this relationship in the genetically diverse South African population. The aim was therefore to evaluate the relationship between predicted and measured CYP2D6 phenotype. An XL-PCR+Sequencing approach was used to determine CYP2D6 genotype in 100...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotransformation
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dextromethorphan

Share to Healthy Volunteers

Share to Pharmacogenomic Testing

Share to Pharmacogenomic Variants

Share to South Africa

Share to Tandem Mass Spectrometry

Source

Identifiers

PMID: 26503815
DOI: 10.1038/tpj.2015.76

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.PMID 26503815Read ↗

Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations.Semantic proximity Read ↗

The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.Semantic proximity Read ↗

Evaluation of cytochrome P450 2D6 phenotyping in healthy adult Western Indians.Semantic proximity Read ↗

Cytochrome P450 2D6 polymorphism in eastern Indian population.Semantic proximity Read ↗

In vivo characterization of CYP2D6*12, *29 and *84 using dextromethorphan as a probe drug: a case report.Semantic proximity Read ↗

The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction.Semantic proximity Read ↗

CYP2D6 genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting.Semantic proximity Read ↗

Clinical Relevance of CYP2D6 Polymorphisms in Patients of an Austrian Medical Practice: A Family Practice-Based Observational StudySemantic proximity Read ↗

Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South African cohort.Semantic proximity Read ↗

CYP2D6 phenotyping with dextromethorphan.Semantic proximity Read ↗

Prediction of CYP2D6 phenotype from genotype across world populations.Semantic proximity Read ↗

Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.