Article
CYP2D6 genotype and phenotype relationship in South Indians.
Journal of postgraduate medicine - 1 Jan 2000
Naveen A T, Prasanna T, Farzana B L, Rajan S, Adithan C
Abstract excerpt
BACKGROUND: Genotypes of the drug-metabolizing enzyme CYP2D6 influence plasma levels of 25% of commonly prescribed drugs. This is the first study in India to investigate the genotype-phenotype relationship of CYP2D6. AIM: To study the influence of some CYP2D6 genotypes on the metabolism of its substrate dextromethorphan in healthy South Indian volunteers and to assess the contribution of the CYP2D6*10 and...
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