Article
Evaluation of CYP2D6 phenotype in the Yoruba Nigerian population.
Expert review of clinical pharmacology - 1 Oct 2017
Adedeji Waheed Adeola, Igbinoba Sharon Iyobor, Fakeye Titilayo O, Oladosu Ibrahim Adebayo, Fehintola Fatai Adewale, Ma Qing, Morse Gene D
Abstract excerpt
BACKGROUND: There is a lack of information on CYP2D6, a major metabolizing enzyme, in Africa ethnic nationalities. The objective was to determine CYP2D6 phenotype in Yoruba Nigerians using dextromethorphan (DEX). METHOD: A total of 89 healthy volunteers received 30 mg of DEX orally followed by blood and urine sample collection at 3-hour and over 8 h post-dose, respectively. DEX and dextrorphan (DOR)...
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