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Identification and drug metabolic activity evaluation of 12 CYP2D6 allelic variants newly detected in the Chinese population.

Gene - 20 May 2026

Chen Chunhong, Geng Peiwu, Liu Rucong, Lu Zebei, Lin Qinrong, Ma Yuntong, Han Aixia, Zhang Qiaoling, Wu Shangqing, Jin Pengfei, Xu Wenfeng, Cai Jianping, Wang Shuanghu, Dai Dapeng

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic gene and a key determinant of interindividual differences in drug metabolism. However, comprehensive characterization of its genetic polymorphisms and their functional consequences in the Chinese Han population still remains limited. This study conducted CYP2D6 genotyping via multiplex PCR amplicon sequencing in 1,211 Chinese Han individuals, identifying 12...

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PMID: 41806934
DOI: 10.1016/j.gene.2026.150094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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