Article
Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations.
Expert opinion on drug metabolism & toxicology - 1 Nov 2014
LLerena Adrián, Naranjo Maria Eugenia G, Rodrigues-Soares Fernanda, Penas-LLedó Eva M, Fariñas Humberto, Tarazona-Santos Eduardo
Abstract excerpt
INTRODUCTION: The frequency of CYP2D6 alleles, related to either a lack of or increased enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM), can vary across ethnic groups and hence across geographic regions. AREAS COVERED: Worldwide original research papers on CYP2D6 allelic frequencies, metabolic phenotype frequencies measured with a probe drug, and/or genotype frequencies...
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