Article
A Review of the Important Role of CYP2D6 in Pharmacogenomics.
Genes - 30 Oct 2020
Taylor Christopher, Crosby Ian, Yip Vincent, Maguire Peter, Pirmohamed Munir, Turner Richard M
Abstract excerpt
Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of ~20% of commonly used drugs across a broad spectrum of medical disciplines including psychiatry, pain management, oncology and cardiology. Nevertheless, CYP2D6 is highly polymorphic with single-nucleotide polymorphisms, small insertions/deletions and larger structural variants including multiplications, deletions, tandem...
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