Article
Influence of CASP9 c.-1339A>G and CASP3 c.-1191A>G variants in outcome of patients with head and neck squamous cell carcinoma.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Nov 2020
Carvalho Bruna Fernandes, Costa Ericka Francislaine Dias, Lopes-Aguiar Leisa, Liutti Vitor Teixeira, Leal Frederico, Vasconcelos Vivian Castro Antunes, Rinck-Junior José Augusto, Lourenço Gustavo Jacob, Lima Carmen Silvia Passos
Abstract excerpt
BACKGROUND: Abnormalities in the intrinsic apoptosis pathway, associated with single nucleotide variants (SNVs) in caspase (CASP) genes, alter head and neck squamous cell carcinoma (HNSCC) proliferation and progression. This prospective study aimed to evaluate whether CASP9 c.-1339A>G and CASP3 c.-1191A>G SNVs influence the outcome of patients with HNSCC. Two hundred sixty-two HNSCC patients were enrolled in the...
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