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Article

Somatic mutations of CASP3 gene in human cancers.

Human genetics - 1 Jul 2004

Soung Young Hwa, Lee Jong Woo, Kim Su Young, Park Won Sang, Nam Suk Woo, Lee Jung Young, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

Failure of apoptosis is one of the hallmarks of cancer. As an execution-phase caspase, caspase-3 plays a crucial role during apoptosis. To explore the possibility that the genetic alterations of CASP3, which encodes caspase-3, might be involved in the development of human tumors, we analyzed the entire coding region and all splice sites of human CASP3 gene for the detection of somatic mutations in a series of 944...

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Source

Identifiers

PMID: 15127291
DOI: 10.1007/s00439-004-1129-3

Genes

CASP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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