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Article

A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2013

Guan Xiaoxiang, Liu Zhensheng, Liu Hongliang, Yu Hongping, Wang Li-E, Sturgis Erich M, Li Guojun, Wei Qingyi

Abstract excerpt

Caspases are important regulators and executioners in the apoptosis pathways and play crucial roles in carcinogenesis. We tested the hypothesis that functional variants of CASP genes are associated with risk of squamous cell carcinoma of the head and neck (SCCHN) and second primary malignancy (SPM). We genotyped 7 selected, potentially functional single nucleotide polymorphisms (SNPs) located in the microRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23271051
DOI: 10.1096/fj.12-223420
PMCID: PMC3606531

Genes

CASP3
CASP6
CASP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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