Genetic variant in CASP3 affects promoter activity and risk of esophageal squamous cell carcinoma.

doi:10.1111/j.1349-7006.2011.02173.x

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Article

Genetic variant in CASP3 affects promoter activity and risk of esophageal squamous cell carcinoma.

Cancer science - 1 Mar 2012

Zhang Zhi, Yu Xinfeng, Guo Yongli, Song Wenguang, Yu Dianke, Zhang Xuemei

Abstract excerpt

Caspase-3 (CASP3) is the main executioner of apoptosis, mediating both extrinsic and intrinsic cell death signaling pathways, and is involved in tumor behaviors. In this study, we investigated the association of two regulatory variants in CASP3 and the risk of esophageal squamous cell carcinoma (ESCC) in 1026 cases and 1270 healthy controls. Odds ratios (OR) and 95% confidence intervals (CI) were computed by...

Topics

Adult
Aged
Aged, 80 and over
Asian People
Carcinoma, Squamous Cell
Caspase 3
Esophageal Neoplasms
Female
Genetic Predisposition to Disease
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Polymorphism, Restriction Fragment Length

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Real-Time Polymerase Chain Reaction

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 22136337
DOI: 10.1111/j.1349-7006.2011.02173.x
PMCID: PMC7713629

Genes

CASP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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