Article
The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.
Cancer prevention research (Philadelphia, Pa.) - 1 Feb 2010
Li Chunying, Lu Jiachun, Liu Zhensheng, Wang Li-E, Zhao Hui, El-Naggar Adel K, Sturgis Erich M, Wei Qingyi
Abstract excerpt
Caspase 8 (CASP8) is an apoptosis-related cysteine peptidase involved in the death receptor pathway and likely in the mitochondrial pathway. A CASP8 promoter region six-nucleotide deletion/insertion (-652 6N ins/del) variant and a coding region D302H polymorphism are reportedly important in cancer development, but no reported study has assessed the associations of these genetic variations with risk of head and...
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