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CASP3 Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck

30 Sept 2008

Abstract excerpt

PURPOSE: Caspase-3 plays a central role in executing cell apoptosis and thus in carcinogenesis, but little is known about the role of CASP3 variants in susceptibility to SCCHN. EXPERIMENTAL DESIGN: Genotype and haplotypes of the first intron (rs4647601:G>T and rs4647602:C>A) and 5'-untranslated region (UTR; rs4647603:G>A) of CASP3 (NT_022792.17) were determined for 930 SCCHN patients and 993 cancer-free controls...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18829519
DOI: 10.1158/1078-0432.ccr-08-1198

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