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Article

Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover.

Nature cell biology - 1 Sept 2020

Aeby Eric, Lee Hun-Goo, Lee Yong-Woo, Kriz Andrea, Del Rosario Brian C, Oh Hyun Jung, Boukhali Myriam, Haas Wilhelm, Lee Jeannie T

Abstract excerpt

How allelic asymmetry is generated remains a major unsolved problem in epigenetics. Here we model the problem using X-chromosome inactivation by developing "BioRBP", an enzymatic RNA-proteomic method that enables probing of low-abundance interactions and an allelic RNA-depletion and -tagging system. We identify messenger RNA-decapping enzyme 1A (DCP1A) as a key regulator of Tsix, a noncoding RNA implicated in...

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PMID: 32807903
DOI: 10.1038/s41556-020-0558-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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